5. Methods

In this software, we utilize two methods to estimate the MRMC variance components of four widely used variance decompositions of the reader-averaged AUC. Then we use these variance decompositions to size a trial. The software can analyze data from a reader-study of two modalities that is fully crossed with readers and cases paired across modalities (every reader reads every case in two modalities).

The contents of 5. Methods

5.1 Introduction to ROC Reader Studies

5.2 Variance Estimation

5.3 Components of Variance

5.4 Hypothesis Testing and Confidence Intervals:

5.5 Sizing a Future Study

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