iRoeMetz: Simulate Roe & Metz model, 3. Run iRoeMetz
3. Run iRoeMetz
iRoeMetz software can be run under 2 models, GUI interface and command line. Both of them are available on Windows, Mac and Linux operation systems.
In GUI interface, users can manually input or load simulation parameters, and use buttons to manage software.
In command line, users can only load parameter from input file, and iRoeMetz will automatically do simulation and statical analysis.
Study parameters include four parts:
1. Model Parameters: Means of 2 modalities; variance components for readers, cases, modalities and interactions.
2. Study Size: Number of readers and cases in each trial.
3. Study Design: Defines whether the study is fully crossed or split-plot. User can also specify whether readers or cases are paired across.
4. Random generator seed and number of Monte Carlo trials: Sets number for study trials and Random Number Generator seed (RNG), with it user can redo the simulation.
The software provides two kinds of statistical analyses Simulation Experiments and Numerical Integration.
Simulation Experiments:
For each trial the software simulates a multiple reader, multiple case ROC reader study based on study parameters, then executes an MRMC analysis of AUC from the data. Finally it estimates the Monte Carlo mean and variance for all trial analyses.
Numerical Integration:
Software directly calculates the MRMC AUC characteristics using numerical integration methods.
