eeDAP: Evaluation Environment for Digital and Analog Pathology, I. Introduction
I. Introduction
This is a tool to design and execute correlated optical and digital pathology reader studies. This application supports two modes of reading, Digital and MicroRT. Digital mode uses a set of regions of interest (ROIs) identified and extracted from digital whole slide images (WSIs). MicroRT mode offers the reader a real-time view of the identical set of ROIs from a glass slide, through the optics of a microscope. In other words, the two modes are registered to one another. Furthermore this tool allows for the administrator of the study to have a high level of control over the format of the tasks presented to the readers through specifications in an input file. Several simple default tasks are available to the administrator: multiple choice, continuous sliders, or binary responses. These simple tasks can be modified through a graphical user interface in conjunction with moderate MATLAB programming skills. Furthermore, the administrator can also specify whether the reader is allowed to pan or zoom while confirming in real time the registration of MicroRT ROIs and Digital ROIs.
The ability to either present the readers with an analog image (MicroRT) or a digital image of the same specimen ROI allows for the reduction or elimination of a large source of variability in comparing these modalities: the cells being viewed. The registration of areas strengthens the evaluation of digital pathology and its comparison to the microscope.
Abbreviations
WSI, WSIs
Whole Slide Image(s)
ROI, ROIs
Region(s) of Interest
MicroRT
Microscope Real-Time Viewing
RT
Real Time
FOV
Field of View
Administrator
The (task) administrator is responsible for task set up and monitoring
